LP-935509
Names
[ CAS No. ]:
1454555-29-3
[ Name ]:
LP-935509
Biological Activity
[Description]:
LP-935509 is a small-molecule adapter protein-2 associated kinase 1 (AAK1) selective and brain-penetrantinhibitor (IC50=3.3 nM), a ATP-competitive inhibitor with a Ki of 0.9 nM. LP-935509 is a potent inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure[1].
[Related Catalog]:
[Target]
IC50: 3.3 nM (AAK1); 14 nM (BIKE); 320 nM (GAK)[1]
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C20H24N6O3
[ Molecular Weight ]:
396.44