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LP-935509

Names

[ CAS No. ]:
1454555-29-3

[ Name ]:
LP-935509

Biological Activity

[Description]:

LP-935509 is a small-molecule adapter protein-2 associated kinase 1 (AAK1) selective and brain-penetrantinhibitor (IC50=3.3 nM), a ATP-competitive inhibitor with a Ki of 0.9 nM. LP-935509 is a potent inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[Target]

IC50: 3.3 nM (AAK1); 14 nM (BIKE); 320 nM (GAK)[1]


[References]

[1]. Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H24N6O3

[ Molecular Weight ]:
396.44


Related Compounds