Propargyl-PEG2-Tos

Names

[ Name ]:
Propargyl-PEG2-Tos

[Synonym ]:
2-(2-propynyloxy)ethanol p-toluenesulfonate
2-(propargyloxy)ethyl p-toluenesulfonate
3-oxohex-5-ynyl tosylate
2-(2-propynyloxy)ethyl tosylate
2-prop-2-ynyloxyethyl p-toluenesulfonate
2-(prop-2-ynyloxy)ethyl p-toluenesulfonate

Biological Activity

[Description]:

Propargyl-PEG2-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₄O₄S

[ Molecular Weight ]:
254.30200

[ Exact Mass ]:
254.06100

[ PSA ]:
60.98000

[ LogP ]:
2.43090

Propargyl-PEG2-Tos

Names

Biological Activity

Chemical & Physical Properties

Related Compounds