<Suppliers Price>

GJ103

Names

[ CAS No. ]:
1459687-89-8

[ Name ]:
GJ103

[Synonym ]:
2-(4-(3-methoxyphenyl)-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid

Biological Activity

[Description]:

GJ103 is a read-through compound that can induce read through of premature stop codons. GJ103 has potential for the research of genetic disorders caused by nonsense mutations[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[In Vivo]

GJ103 (10-30 μM; 4 days) 在具有纯合 TGA 突变和纯合 TAA 突变的 AT153LA 细胞中诱导 ATM 激酶活性[1]。 GJ103 在浓度高达 300 µM 时对 A-T 细胞没有表现出明显的细胞毒性[1]。

[References]

[1]. Du L, et, al. A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene. Mol Ther. 2013 Sep;21(9):1653-60.  

Chemical & Physical Properties

[ Molecular Formula ]:
C16H14N4O3S

[ Molecular Weight ]:
342.378

[ Appearance of Characters ]:
yellow

Related Compounds