triflupromazine
Names
[ CAS No. ]:
146-54-3
[ Name ]:
triflupromazine
[Synonym ]:
dimethyl-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-amine
Siquil
EINECS 205-673-6
N,N-dimethyl-2-(trifluoromethyl)-10H-phenothiazine-10-propanamine
Adazine
Vesprin
Triflupromazina
Vetame
Psyquil
Triflupromazinum
Trifluopromazine
2-trifluoromethyl-10-[3-(dimethylamino)propyl]phenothiazine
N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine
Fluopromazine
Chemical & Physical Properties
[ Density]:
1.238g/cm3
[ Boiling Point ]:
427.6ºC at 760mmHg
[ Melting Point ]:
25°C
[ Molecular Formula ]:
C18H19F3N2S
[ Molecular Weight ]:
352.41700
[ Flash Point ]:
212.4ºC
[ Exact Mass ]:
352.12200
[ PSA ]:
31.78000
[ LogP ]:
5.32480
[ Index of Refraction ]:
nD23 1.5780
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SO8850000
- CHEMICAL NAME :
- Phenothiazine, 10-(3-(dimethylamino)propyl)-2-(trifluoromethyl)-
- CAS REGISTRY NUMBER :
- 146-54-3
- LAST UPDATED :
- 199201
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C18-H19-F3-N2-S
- MOLECULAR WEIGHT :
- 352.45
- WISWESSER LINE NOTATION :
- T C666 BN ISJ B3N1&1 EXFFF
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 185 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 94 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 245 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 34 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 25 mg/kg
- SEX/DURATION :
- male 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 17,87,1973
Safety Information
[ HS Code ]:
2934300000
Customs
[ HS Code ]: 2934300000
[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%