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SR 2640 hydrochloride

Names

[ CAS No. ]:
146662-42-2

[ Name ]:
SR 2640 hydrochloride

[Synonym ]:
2-{[3-(2-Quinolinylmethoxy)phenyl]amino}benzoic acid hydrochloride (1:1)
2-{[3-(Quinolin-2-ylmethoxy)phenyl]amino}benzoic acid hydrochloride (1:1)
Benzoic acid, 2-[[3-(2-quinolinylmethoxy)phenyl]amino]-, hydrochloride (1:1)
MFCD04971976

Biological Activity

[Description]:

SR2640 (hydrochloride) is a potent and selective competitive leukotriene D4/leukotriene E4 antagonist. SR2640 can be used for researching the role of leukotrienes in human asthma[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor
Research Areas >> Inflammation/Immunology

[Target]

LTD4 and LTE4[1]


[In Vivo]

SR2640 inhibits the LTD 4-induced contractions of guinea-pig ileum in a concentration-dependent manner, with an IC50 of 3 nM[1]. SR2640 (1 mg/kg; IV; single dosage) specifically prevents the contractile responses of guinea-pig ileum and trachea to LTD4 and LTE4[1]. Animal Model: Guinea pigs (injected with LTD4 and LTE4)[1] Dosage: 1 mg/kg Administration: IV; single dosage Result: Specifically prevented the contractile responses of guinea-pig ileum and trachea to LTD4 and LTE4.

[References]

[1]. Ahnfelt-Rønne I, Kirstein D, Kaergaard-Nielsen C. A novel leukotriene D4/E4 antagonist, SR2640 (2-[3-(2-quinolylmethoxy)phenylamino]benzoic acid). Eur J Pharmacol. 1988;155(1-2):117-128.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H19ClN2O3

[ Molecular Weight ]:
406.86

[ Exact Mass ]:
406.108429

Related Compounds