PAPA NONOate

Names

[ Name ]:
PAPA NONOate

[Synonym ]:
3-(2-hydroxy-2-nitroso-1-propylhydrazino)-1-propanamine
1-Propanamine, 3-(2-hydroxy-3-oxo-1-propyltriazanyl)-
1-Hydroxy-2-oxo-3-(3-aminopropyl)-3-propyl-1-triazene
PAPA NONOate
1-Propanamine,3-(2-hydroxy-2-nitroso-1-propylhydrazinyl)
1-(3-Aminopropyl)-2-hydroxy-3-oxo-1-propyltriazane
NOC-15

Biological Activity

[Description]:

PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential treatment for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site[1][2][3].

[Related Catalog]:

Research Areas >> Endocrinology

[In Vitro]

PAPA NONOate (50 μM; 12 h) significantly reduces 70% caspase-3-like activity in caspase-3-overexpressing HUVEC and abolishs the induction of cell death by caspase-3[1].

[In Vivo]

PAPA NONOate (100 μM in phosphate buffer) increases the rate of wound healing in rats with diabetes and wound[2]. Animal Model: Anesthetized male Sprague-Dawley rats with streptozotocin-induced diabetes and full thickness dermal wound[2] Dosage: 100 μM Administration: Wounds received 100 μM PAPA NONOate in phosphate buffer Result: Increased the wound healing rate in test group.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
277.2±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆H₁₆N₄O₂

[ Molecular Weight ]:
176.217

[ Flash Point ]:
121.4±27.9 °C

[ Exact Mass ]:
176.127319

[ PSA ]:
82.16000

[ LogP ]:
0.20

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.523

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R22