SRS11-92
Names
[ CAS No. ]:
1467047-25-1
[ Name ]:
SRS11-92
[Synonym ]:
Benzoic acid, 4-(cyclohexylamino)-3-[(phenylmethyl)amino]-, ethyl ester
Ethyl 3-(benzylamino)-4-(cyclohexylamino)benzoate
Biological Activity
[Description]:
SRS11-92 (SRS 11-92) is a small molecule inhibitor of Ferroptosis and a derivative of Ferrostatin-1 (Fer-1), inhibits ferroptotic cell death induced by erastin in HT-1080 human fibrosarcoma cells with EC50 of 6 nM; inhibits iron-induced cell death in isolated mouse kidney proximal tubules at 2 uM, and fully protects rat oligodendrocytes from cystine deprivation-induced cell death in an in vitro model of periventricular leukomalacia when used at a concentration of 100 nM; also increases survival of medium spiny neurons in rat corticostriatal brain slices in an in vitro model of Huntington’s disease in a concentration-dependent manner.
[References]
References 1. Cotticelli MG, et al. J Pharmacol Exp Ther. 2019 Jan 11. pii: jpet.118.252759. 2. Linkermann A, et al. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16836-41. View Related Products by Target Ferroptosis
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
523.7±45.0 °C at 760 mmHg
[ Molecular Formula ]:
C22H28N2O2
[ Molecular Weight ]:
352.470
[ Flash Point ]:
270.5±28.7 °C
[ Exact Mass ]:
352.215088
[ LogP ]:
6.37
[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C
[ Index of Refraction ]:
1.619