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6H05

Names

[ CAS No. ]:
1469338-01-9

[ Name ]:
6H05

[Synonym ]:
4-Thiazolidinone, 5-[(4-ethylphenyl)methylene]-3-[4-oxo-4-(10H-phenothiazin-10-yl)butyl]-2-thioxo-, (5Z)-
(5Z)-5-(4-Ethylbenzylidene)-3-[4-oxo-4-(10H-phenothiazin-10-yl)butyl]-2-thioxo-1,3-thiazolidin-4-one
6H05

Biological Activity

[Description]:

6H05 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C). IC50 value:Target: K-Ras G12C6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras [1]. 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors [2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Ras
Research Areas >> Cancer

[References]

[1]. Ostrem JM, et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-51.

[2]. Lu S, et al. Harnessing allostery: a novel approach to drug discovery. Med Res Rev. 2014 Nov;34(6):1242-85.


[Related Small Molecules]

ARS-853 | ARS-1620 | NSC 23766 | ML 141 | Salirasib | Pan-RAS-IN-1 | Rhosin hydrochloride | CASIN | EHT 1864 | EHop-016 | 1A-116 | CCG 1423 | K-Ras(G12C) inhibitor 12 | ZCL 278 | Y16

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
735.5±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H30ClN3O2S3

[ Molecular Weight ]:
476.12

[ Flash Point ]:
398.6±35.7 °C

[ LogP ]:
5.65

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.752

[ Storage condition ]:
2~8°C

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds