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Talsaclidine

Names

[ CAS No. ]:
147025-53-4

[ Name ]:
Talsaclidine

[Synonym ]:
WAL 2014
Talsaclidine

Biological Activity

[Description]:

Talsaclidine is a muscarinic agonist with preferential neuron-stimulating properties. Talsaclidine is a full agonist at the M1 subtype, and as a partial agonist at the M2 and M3 subtypes[1][2][3][4].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR
Signaling Pathways >> GPCR/G Protein >> mAChR
Research Areas >> Neurological Disease

[References]

[1]. Ensinger HA, et al. WAL 2014--a muscarinic agonist with preferential neuron-stimulating properties. Life Sci. 1993;52(5-6):473-80.

[2]. Wienrich M, et al. Pharmacodynamic profile of the M1 agonist talsaclidine in animals and man. Life Sci. 2001 Apr 27;68(22-23):2593-600.

[3]. Walland A, et al. In vivo consequences of M1-receptor activation by talsaclidine. Life Sci. 1997;60(13-14):977-84.

[4]. Walland A, et al. Compensation of muscarinic bronchial effects of talsaclidine by concomitant sympathetic activation in guinea pigs. Eur J Pharmacol. 1997 Jul 9;330(2-3):213-9.

Chemical & Physical Properties

[ Density]:
1.06g/cm3

[ Boiling Point ]:
251.1ºC at 760mmHg

[ Molecular Formula ]:
C10H15NO

[ Molecular Weight ]:
165.23200

[ Flash Point ]:
73.3ºC

[ Exact Mass ]:
165.11500

[ PSA ]:
12.47000

[ LogP ]:
0.66830

[ Vapour Pressure ]:
0.0208mmHg at 25°C

[ Index of Refraction ]:
1.525

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R41

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

Related Compounds