TCMDC-125509
Names
[ CAS No. ]:
1476-98-8
[ Name ]:
TCMDC-125509
[Synonym ]:
hydroquinidine,monohydrochloride
Einecs 216-024-1
dihydrochinidinhydrochlorid
(9S)-6'-Methoxy-10,11-dihydrocinchonan-9-ol hydrochloride (1:1)
Hydroquinidine Hydrochloride
Hydroquindine Hydrochloride
Hydroquinidine HCl
TCMDC-125509
MFCD00135598
Cinchonan-9-ol, 10,11-dihydro-6'-methoxy-, (9S)-, hydrochloride (1:1)
Dihydroquinidine Hydrochloride
Chemical & Physical Properties
[ Density]:
1.2g/cm3
[ Boiling Point ]:
498.4ºC at 760mmHg
[ Melting Point ]:
277-279ºC(lit.)
[ Molecular Formula ]:
C20H27ClN2O2
[ Molecular Weight ]:
362.894
[ Flash Point ]:
255.2ºC
[ Exact Mass ]:
362.176117
[ PSA ]:
45.59000
[ LogP ]:
4.13710
[ Vapour Pressure ]:
9.92E-12mmHg at 25°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MX3018000
- CHEMICAL NAME :
- Hydroquinidine, monohydrochloride
- CAS REGISTRY NUMBER :
- 1476-98-8
- LAST UPDATED :
- 199312
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C20-H26-N2-O2.Cl-H
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 369 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,589,1977
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 52,2797,1992
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 32 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,589,1977
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 52,2797,1992
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
36
[ RIDADR ]:
UN 1544
[ RTECS ]:
MX3018000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
Articles
Antimicrob. Agents Chemother. 56(10) , 5356-64, (2012)
The Cinchona alkaloids are quinoline aminoalcohols that occur as diastereomer pairs, typified by (-)-quinine and (+)-quinidine. The potency of (+)-isomers is greater than the (-)-isomers in vitro and ...
Modified asymmetric Strecker reaction of aldehyde with secondary amine: a protocol for the synthesis of S-clopidogrel (an antiplatelet agent).J. Org. Chem. 77(16) , 7076-80, (2012)
A first approach for catalytic asymmetric Strecker reaction of aldehydes with a secondary amine in the presence of sodium fluoride using hydroquinine as chiral catalyst was developed. The catalytic sy...
Calculation of standard electrode potential of half reaction for benzoquinone and hydroquinone.Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 65(2) , 333-9, (2006)
Geometric parameters, the vibrational frequencies and thermochemical values of benzoquinone and hydroquinone were computed using ab initio molecular orbital calculations (HF) and density function theo...