PXS-4681A
Names
[ CAS No. ]:
1478364-87-2
[ Name ]:
PXS-4681A
Biological Activity
[Description]:
A potent, selective, and irreversible inhibitor of SSAO/VAP-1 (AOC3) with Ki of 37 nM, IC50 of <10 nM; displays 250- and 4000-fold selectivity over DAO and LOX; attenuates neutrophil migration, TNF-α, and IL-6 levels in mouse models of lung inflammation and localized inflammation;orally activie.
[References]
References 1. Foot JS, et al. J Pharmacol Exp Ther. 2013 Nov;347(2):365-74. 2. Becchi S, et al. Br J Pharmacol. 2017 Jul;174(14):2302-2317. View Related Products by Target Other Targets
Chemical & Physical Properties
[ Molecular Formula ]:
C10H14ClFN2O3S
[ Molecular Weight ]:
296.741