2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-(trifluoromethyl)-, 1,1-dioxide
Names
[ CAS No. ]:
148-56-1
[ Name ]:
2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-(trifluoromethyl)-, 1,1-dioxide
[Synonym ]:
Trifluoromethylthiazide
Flumethazide
Trifluomethylthiazide
Fludemil
Ademol
Ademil
Flumetiazid
EINECS 205-717-4
6-Trifluormethyl-7-sulfamoyl-2H-benzo-1,2,4-thiadiazol-S,S-dioxid
6-trifluoromethyl-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide
Flumethiazid
7-Sulfamoyl-6-trifluormethyl-1,2,4-benzothiadiazin-dioxid-(1,1)
Routrax
Flumethiazide
Chemical & Physical Properties
[ Density]:
1.99g/cm3
[ Boiling Point ]:
560ºC at 760mmHg
[ Molecular Formula ]:
C8H6F3N3O4S2
[ Molecular Weight ]:
329.27600
[ Exact Mass ]:
328.97500
[ PSA ]:
135.45000
[ LogP ]:
2.93080
[ Index of Refraction ]:
1.673
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DK9800000
- CHEMICAL NAME :
- 4H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-(trifluoromethyl)-, 1,1-dioxide
- CAS REGISTRY NUMBER :
- 148-56-1
- LAST UPDATED :
- 199601
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C8-H6-F3-N3-O4-S2
- MOLECULAR WEIGHT :
- 329.29
- WISWESSER LINE NOTATION :
- T66 BSWM ENJ HXFFF ISZW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >8 gm/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 134,273,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1760 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 134,273,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 910 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - ataxia Gastrointestinal - changes in structure or function of salivary glands
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 128,405,1960
Safety Information
[ HS Code ]:
2935009090
Customs
[ HS Code ]: 2935009090
[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%