Prion Protein 106-126 (human)

Names

[ Name ]:
Prion Protein 106-126 (human)

[Synonym ]:
Prion Protein Fragment 106-126 Human
N-MPPP Hydrochloride

Biological Activity

[Description]:

Prion Protein 106-126 (human) is a peptide fragment of prion, it can induct neuronal apoptosis, antiproteinase K digestion, fiber formation, and mediate the conversion of normal cellular prion protein (PrPc) into pathogenic isoform (PrPSc). Prion Protein 106-126 (human) is generally used as the model to investigate neural degeneration of prion disease[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Neurological Disease

[References]

[1]. Forloni G, et, al. Neurotoxicity of a prion protein fragment. Nature. 1993 Apr 8; 362(6420): 543-6.

[2]. Hong JM, et, al. Human prion protein-mediated calcineurin activation induces neuron cell death via AMPK and autophagy pathway. Int J Biochem Cell Biol. 2020 Feb; 119: 105680.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈₀H₁₃₈N₂₆O₂₄S₂

[ Molecular Weight ]:
1912.24000

[ Exact Mass ]:
1910.98000

[ PSA ]:
839.96000

[ LogP ]:
0.33420

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport