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Me-triacetyl-β-D-glucopyranuronate-Ph-ald-NO2

Names

[ CAS No. ]:
148579-93-5

[ Name ]:
Me-triacetyl-β-D-glucopyranuronate-Ph-ald-NO2

[Synonym ]:
4-Formyl-2-nitrophenyl methyl 2,3,4-tri-O-acetyl-β-D-glucopyranosiduronate
Benzaldehyde, 3-nitro-4-[(2,3,4-tri-O-acetyl-6-methyl-β-D-glucopyranuronosyl)oxy]-

Biological Activity

[Description]:

Me-triacetyl-β-D-glucopyranuronate-Ph-ald-NO2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Research Areas >> Inflammation/Immunology

[Target]

Cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Benatuil, Lorenzo, et al. Anti-B7-H3 antibodies and antibody drug conjugates. WO2017214339.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
582.6±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H21NO13

[ Molecular Weight ]:
483.380

[ Flash Point ]:
219.6±32.1 °C

[ Exact Mass ]:
483.101288

[ LogP ]:
2.62

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.550

Related Compounds