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Epigallocatechin gallate octaacetate

Names

[ CAS No. ]:
148707-39-5

[ Name ]:
Epigallocatechin gallate octaacetate

[Synonym ]:
(-)-Epigallocatechin gallate peracetate
(2R,3R)-5,7-bis(acetoxy)-2-[3',4',5'-tris(acetoxy)phenyl]chroman-3-yl 3,4,5-tris(acetoxy)benzoate
peracetyl EGCG
5-(((2R,3R)-5,7-diacetoxy-2-(3,4,5-triacetoxyphenyl)chroman-3-yloxy)carbonyl)benzene-1,2,3-triyl triacetate
3,4,5-Triacetoxy-benzoic acid (2R,3R)-5,7-diacetoxy-2-(3,4,5-triacetoxy-phenyl)-chroman-3-yl ester
EGCG peracetate
EGCG octaacetate

Biological Activity

[Description]:

EGCG Octaacetate is a prodrug of Green tea epigallocatechin-3-gallate (EGCG), utilized to enhance the stability and bioavailability of EGCG in vivo. EGCG Octaacetate has high efficacy, bioavailability, anti-oxidation and anti-angiogenesis capacities[1]. EGCG octaacetate is the potential antibacterial compound for gram-positive bacteria (GPB) and gram-negative bacteria (GNB) [2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Wang CC, et al. Prodrug of green tea epigallocatechin-3-gallate (Pro-EGCG) as a potent anti-angiogenesis agent for endometriosis in mice. Angiogenesis. 2013 Jan;16(1):59-69.

[2]. KalaiselviIgnasimuthu, et al. Enhanced bioaccessibility of green tea polyphenols and lipophilic activity of EGCG octaacetate on gram-negative bacteria. Volume 105, May 2019, Pages 103-109.

Chemical & Physical Properties

[ Density]:
1.46±0.1 g/cm3(Predicted)

[ Boiling Point ]:
879.7±65.0 °C(Predicted)

[ Melting Point ]:
114.3-115.1 °C

[ Molecular Formula ]:
C38H34O19

[ Molecular Weight ]:
794.66500

[ Exact Mass ]:
794.16900

[ PSA ]:
245.93000

[ LogP ]:
3.99080

Related Compounds