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AQC

Names

[ CAS No. ]:
148757-94-2

[ Name ]:
AQC

[Synonym ]:
AHC reagent
{[3-(6-Amino-2-quinolinyl)-2,5-dioxo-1-pyrrolidinyl](carboxy)amino}oxidanide
AccQ.Fluor
Carbamato, N-[3-(6-amino-2-quinolinyl)-2,5-dioxo-1-pyrrolidinyl]-N-hydroxy-, ion(1-)
Carbamic acid,N-6-quinolinyl-,2,5-dioxo-1-pyrrolidinyl ester
6-Aminoquinolyl-N-hydroxysuccinimidylcarbamate

Biological Activity

[Description]:

AQC (6-Aminoquinolyl-N-hydroxysccinimidyl carbamate) is a reagent used in for amino acid or protein sequence analysis by HPLC with fluorescence detection. AQC reacts with primary and secondary amino acids to yield fluorescent derivates, allowing amino acid detection at under-picomolar levels[1][2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

The use of AQC (6-Aminoquinolyl-N-hydroxysccinimidyl carbamate), which reacts with primary and secondary amino acids to yield fluorescent derivates (λ excitation and emission at 250 and 395 nm, respectively), allowing amino acid detection at under-picomolar levels, overcomes many of the drawbacks associated with the rest of derivatising reagents[1][2].

[References]

[1]. Bosch L, et al. Application of the 6-aminoquinolyl-N-hydroxysccinimidyl carbamate (AQC) reagent to the RP-HPLC determination of amino acids in infant foods. J Chromatogr B Analyt Technol Biomed Life Sci. 2006;831(1-2):176-183.

[2]. Cohen SA, et al. Applications of amino acid derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate. Analysis of feed grains, intravenous solutions and glycoproteins. J Chromatogr A. 1994;661(1-2):25-34.

Chemical & Physical Properties

[ Boiling Point ]:
661.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H11N3O4

[ Molecular Weight ]:
315.262

[ Flash Point ]:
353.5±34.3 °C

[ Exact Mass ]:
315.073486

[ PSA ]:
139.89000

[ LogP ]:
-1.98

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

Related Compounds