Ac-Tyr-Val-Ala-Asp-AMC
Names
[ CAS No. ]:
149231-65-2
[ Name ]:
Ac-Tyr-Val-Ala-Asp-AMC
[Synonym ]:
acetyl-YVAD-aminomethyl coumarine
Ac-Tyr-Val-Ala-Asp-7-Amino-4-Methylcoumarin
N-Acetyl-L-tyrosyl-L-valyl-L-alanyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-α-asparagine
Acetyl-YVAD-AMC
N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-methylcoumarin
L-α-Asparagine, N-acetyl-L-tyrosyl-L-valyl-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
MFCD00171369
Ac-Tyr-Val-Ala-Asp-MCA
Ac-YVAD-AMC
Ac-Tyr-Val-Ala-Asp-AMC
AMC120
AC-YVAD-AMC
AC-TYR-VAL-ALA-ASP-AMC
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
1127.3±65.0 °C at 760 mmHg
[ Molecular Formula ]:
C33H39N5O10
[ Molecular Weight ]:
665.690
[ Flash Point ]:
635.6±34.3 °C
[ Exact Mass ]:
665.269714
[ PSA ]:
233.24000
[ LogP ]:
2.58
[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.605
[ Storage condition ]:
−20°C
[ Water Solubility ]:
DMSO: 10 mM The solution is stable in the dark at −20 °C for more than 1 month if no water is present.
MSDS
Safety Information
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
Precursor & DownStream
Precursor
DownStream
Articles
Nature 356 , 768, (1992)
Interleukin-1 beta (IL-1 beta)-converting enzyme cleaves the IL-1 beta precursor to mature IL-1 beta, an important mediator of inflammation. The identification of the enzyme as a unique cysteine prote...
Processing/activation of CPP32-like proteases is involved in transforming growth factor beta1-induced apoptosis in rat hepatocytes.Hepatology 25 , 1516, (1997)
Apoptosis induced in rat hepatocytes by transforming growth factor beta1 (TGF-beta1) was accompanied by the activation of interleukin-1beta converting enzyme (ICE)-like proteases. Cell lysates were is...
Partial purification and characterization of two distinct types of caspases from human epidermis.J. Invest. Dermatol. 111 , 367-372, (1998)
Recent observations demonstrated that interleukin-1beta converting enzyme family proteases, now referred to as caspase family, play central roles in apoptosis, or programmed cell death. In this study,...