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Ac-YVAD-pNA

Names

[ CAS No. ]:
149231-66-3

[ Name ]:
Ac-YVAD-pNA

[Synonym ]:
Ac-Tyr-Val-Ala-Asp-PNA
IL-1beta Converting Enzyme (ICE) Colorimetric Substrate
Ac-Tyr-Val-Ala-Asp-paranitroanilide
L-α-Asparagine, N-acetyl-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-
N-Acetyl-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-L-α-asparagine
Caspase-1 Substrate IV,Colorimetric
Ac-YVAD-pNA

Biological Activity

[Description]:

Ac-YVAD-pNA is a specific Caspase-1 substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Caspase
Research Areas >> Inflammation/Immunology

[Target]

Caspase-1


[References]

[1]. Pereira NA, et al. Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity. Biochem Biophys Res Commun. 2008 Dec 19;377(3):873-7.  

[2]. Xin W, Wang Q, et al. A new mechanism of inhibition of IL-1β secretion by celastrol through the NLRP3 inflammasome pathway. Eur J Pharmacol. 2017 Nov 5;814:240-247.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
1108.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C29H36N6O10

[ Molecular Weight ]:
628.63

[ Flash Point ]:
624.5±34.3 °C

[ Exact Mass ]:
628.249268

[ PSA ]:
248.85000

[ LogP ]:
2.61

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.605

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds