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2-MPMDQ

Names

[ CAS No. ]:
149847-77-8

[ Name ]:
2-MPMDQ

[Synonym ]:
Imidazo[1,2-c]quinazolin-5(3H)-one, 2,6-dihydro-2-[[4-(2-methoxyphenyl)-1-piperazinyl]methyl]-6-methyl-
2-{[4-(2-Methoxyphenyl)-1-piperazinyl]methyl}-6-methyl-2,6-dihydroimidazo[1,2-c]quinazolin-5(3H)-one
2-{[4-(2-Methoxyphenyl)piperazin-1-yl]methyl}-6-methyl-2,6-dihydroimidazo[1,2-c]quinazolin-5(3H)-one

Biological Activity

[Description]:

2-MPMDQ is a potent and selective α1-adrenoceptor (Ki=0.37 nM) antagonist over α2-adrenoceptor (Ki=1740 nM). 2-MPMDQ is potent anti-hypertensive agent and has the potential for hypertension research[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[Target]

α1-adrenergic receptor:0.37 nM (Ki)

α2-adrenergic receptor:1740 nM (Ki)


[References]

[1]. J W Chern, et al. Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: a novel class of potent and selective alpha 1-adrenoceptor antagonists and antihypertensive agents. J Med Chem. 1993 Jul 23;36(15):2196-207.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
578.2±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H27N5O2

[ Molecular Weight ]:
405.49

[ Flash Point ]:
303.5±32.9 °C

[ Exact Mass ]:
405.216461

[ LogP ]:
1.60

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.676

Related Compounds