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5-Fluorouridine 5'-O-β-D-galactopyranoside

Names

[ CAS No. ]:
149965-92-4

[ Name ]:
5-Fluorouridine 5'-O-β-D-galactopyranoside

[Synonym ]:
MFCD06799389

Biological Activity

[Description]:

5-Fluorouridine 5'-O-β-D-galactopyranoside (5'-O-β-D-galactosyl-5-fluorouridine) is a 5-Fluorouridine prodrug. 5-Fluorouridine 5'-O-β-D-galactopyranoside can be converted by the enzyme β-D-galactosidase to the potent antineoplastic agent 5-Fluorouridine[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

The ratio of the IC50 of 5-Fluorouridine 5'-O-β-D-galactopyranoside (5'-O-β-D-galactosyl-5-fluorouridine) to that of 5-Fluorouridine determined on a variety of tumor cell lines in vitro ranged from 500:1-1000:1[1].

[In Vivo]

5-Fluorouridine 5'-O-β-D-galactopyranoside (5'-O-β-D-galactosyl-5-fluorouridine) is more than 100x less toxic than 5-Fluorouridine to bone marrow cells in Balb/c mice[1].

[References]

[1]. R Abraham, et al. Conjugates of COL-1 monoclonal antibody and beta-D-galactosidase can specifically kill tumor cells by generation of 5-fluorouridine from the prodrug beta-D-galactosyl-5-fluorouridine. Cell Biophys. 1994;24-25:127-33.

Chemical & Physical Properties

[ Density]:
1.815g/cm3

[ Molecular Formula ]:
C15H21FN2O11

[ Molecular Weight ]:
424.33200

[ Exact Mass ]:
424.11300

[ PSA ]:
203.93000

[ Index of Refraction ]:
1.668

Related Compounds