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Decanoyl-RVKR-CMK

Names

[ CAS No. ]:
150113-99-8

[ Name ]:
Decanoyl-RVKR-CMK

[Synonym ]:
decanoyl RVKR-CMK
N-Decanoyl-N-(diaminomethylene)-L-ornithyl-L-valyl-N-{(3S)-1-chloro-6-[(diaminomethylene)amino]-2-oxo-3-hexanyl}-L-lysinamide
decanoyl-Arg-Val-Lys-Arg-chloromethylketone
Decanoic acid,4-formyl-2-methoxyphenyl ester
L-Lysinamide, N-(diaminomethylene)-N-(1-oxodecyl)-L-ornithyl-L-valyl-N-[(1S)-1-(2-chloroacetyl)-4-[(diaminomethylene)amino]butyl]-
4-formyl-2-methoxyphenyl decanoate
decanoyl vanillin
decanoyl-RVKR-chloromethylketone
Dec-RVKR-CMK

Biological Activity

[Description]:

Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits over-expressed gp160 processing and HIV-1 replication[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection
Research Areas >> Inflammation/Immunology

[In Vitro]

Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits HIV-2ROD replication by blocking envelope glycoprotein precursor processing in the Jurkat lymphocyte cell[1].Decanoyl-RVKR-CMK (DecRVKRcmk) blocks regulated secretion of VGF[2]. Cell Viability Assay Cell Line: HeLaCD4 cells infected with recombinant vaccinia viruses at a multiplicity of infection (MOI) of 5 PFU/mL[1]. Concentration: 35 and 70 µΜ. Incubation Time: 7 days. Result: Peptide at 35 µM significantly inhibited ex vivo HIV-1 and HIV-2 replications (70–80% inhibition).

[References]

[1]. B Bahbouhi, et al. Inhibition of HIV-2(ROD) replication in a lymphoblastoid cell line by the alpha1-antitrypsin Portland variant (alpha1-PDX) and the decRVKRcmk peptide: comparison with HIV-1(LAI). Microbes Infect. 2001 Nov;3(13):1073-84.

[2]. Angelo L Garcia, et al. A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. J Biol Chem. 2005 Dec 16;280(50):41595-608.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C34H66ClN11O5

[ Molecular Weight ]:
744.41

[ Exact Mass ]:
743.493713

[ PSA ]:
283.29000

[ LogP ]:
3.38

[ Index of Refraction ]:
1.585

Related Compounds