QO IIR
Names
[ CAS No. ]:
150404-10-7
[ Name ]:
QO IIR
[Synonym ]:
(E)-3-(3,4-Dihydroxy-2-nitrophenyl)-1-phenylprop-2-en-1-one
Biological Activity
[Description]:
QO IIR is a reversible, tight-binding inhibitor inhibitor of catechol-O-methyltransferase (COMT) with IC50 of 320 nM; fully reverses the reserpine-induced catalepsy in vivo, demonstrates behavioural and neurochemical effects in reserpinized rats treated with LD/CD.
[References]
References 1. Rivas E, et al. Br J Pharmacol. 1999 Apr;126(7):1667-73. 2. Pérez RA, et al. Biochem Pharmacol. 1993 May 25;45(10):1973-81. View Related Products by Target COMT
Chemical & Physical Properties
[ Molecular Formula ]:
C15H11NO5
[ Molecular Weight ]:
285.25
[ Exact Mass ]:
285.063722