sodium 2-(4-methoxyphenoxy) propionate

Names

[ Name ]:
sodium 2-(4-methoxyphenoxy) propionate

[Synonym ]:
2-(4-Methoxyphenoxy)propanoic acid
PMP
(±)-2-(p-Methoxyphenoxy)propionic acid
UNII:K573UZ6O8U
Propanoic acid, 2-(4-methoxyphenoxy)-
2-(4-Methoxyphenoxy)propionic acid

Biological Activity

[Description]:

Lactisole is a canonical antagonist of sweet taste receptor, selectively targeting to T1R3 subunit, a glucose-sensing receptor. Lactisole inhibits insulin secretion induced by glucose in mouse islets[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[Target]

T1R3[1]

[In Vitro]

Lactisole (3-10 mM; 48 h) 在小鼠胰腺 β 细胞 MIN6 中抑制 Acesulfame-K、Sucralose (HY-N0614) 和 Glycyrrhizin (HY-N0184) 诱导的胰岛素分泌 (IC50~4 mM)[1]。 Lactisole (5 mM; 48 h) 可减弱由 Sucralos 和 Acesulfame-K 引起的细胞质 Ca2+ 浓度升高 ([Ca2+]c)，而不影响细胞内 cAMP 浓度升高 ([cAMP]c)[1]。

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
331.6±17.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₂O₄

[ Molecular Weight ]:
196.200

[ Flash Point ]:
130.3±14.4 °C

[ Exact Mass ]:
196.073563

[ PSA ]:
55.76000

[ LogP ]:
1.65

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.521

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

sodium 2-(4-methoxyphenoxy) propionate

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds