Nec-3a

Names

[ CAS No. ]:
1504558-72-8

[ Name ]:
Nec-3a

Biological Activity

[Description]:

Nec-3a is a Necrostatin-3 analogue. Nec-3a is a RIP1 inhibitor (IC50: 0.44 μM). Nec-3a inhibits the autophosphorylation activity of the RIP1 kinase domain[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Apoptosis >> RIP kinase

[Target]

RIPK1:0.44 μM (IC50)


[References]

[1]. Xie T, et al. Structural basis of RIP1 inhibition by necrostatins. Structure. 2013 Mar 5;21(3):493-9.  

Chemical & Physical Properties

[ Molecular Formula ]:
C21H18F4N2O4

[ Molecular Weight ]:
438.37

Related Compounds