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BC-1258

Names

[ CAS No. ]:
1507370-40-2

[ Name ]:
BC-1258

[Synonym ]:
MFCD28137686
N,N'-Bis[4-(1,3-thiazol-2-yl)benzyl]-1,2-ethanediamine
1,2-Ethanediamine, N1,N2-bis[[4-(2-thiazolyl)phenyl]methyl]-
BC-1258

Biological Activity

[Description]:

BC-1258, an F-box/LRR-repeat protein 2 (FBXL2) activator, can stabilize and upregulate FBXL2 levels. BC-1258 induces apoptosis of tumorigenic cells, and profoundly inhibits tumor formation in mice[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[Target]

FBXL2[1]


[In Vitro]

BC-1258 是一种 F-box/LRR-重复蛋白 2 (FBXL2) 激活剂，可以稳定和上调 FBXL2 水平。BC-1258 诱导致瘤细胞凋亡，并显着抑制小鼠的肿瘤形成。 Cell Cycle Analysis[1] Cell Line: MLE cells Concentration: 2, 10, 50 μg/mL Incubation Time: 16 hours Result: Significantly increased the cell population within the G2/M phase. Reduced the diploid cell population and increase the numbers of polyploidal cells in a dose-dependent manner. Western Blot Analysis[1] Cell Line: U937, K562 and THP1 cells Concentration: 2, 10 μg/mL Incubation Time: 16 hours Result: Increased FBXL2 protein levels. Decreased FBXL2 substrates, including Aurora B, cyclin D2 and cyclin D3 levels.

[In Vivo]

BC-1258 (30 μg/mL in the drinking water) significantly reduces tumor size and weight in athymic nude mice[1].

[References]

[1]. Chen BB, et, al. Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis. Cell Death Dis. 2013 Aug 8;4(8):e759.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
599.9±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H22N4S2

[ Molecular Weight ]:
406.567

[ Flash Point ]:
316.6±32.9 °C

[ Exact Mass ]:
406.128601

[ LogP ]:
4.90

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.641

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
NONH for all modes of transport

Related Compounds