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Immepip

Names

[ CAS No. ]:
151070-83-6

[ Name ]:
Immepip

Biological Activity

[Description]:

Immepip is a H3 agonist. Immepip can reduce cortical histamine release. Immepip can be used for the research of neurological diseases[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[In Vivo]

Immepip (i.p.; 5, 10 mg/kg) 显著减少皮质组胺释放，但仅微弱地促进大鼠睡眠[1]。 Animal Model: Sprague-Dawley rats[1] Dosage: 5, 10 mg/kg Administration: Intraperitoneally Result: Significantly modulated brain histamine release and slight, albeit significant, decreased in sleep onset latency.

[References]

[1]. Yves Lamberty, et al. H3 agonist immepip markedly reduces cortical histamine release, but only weakly promotes sleep in the rat. Pharmacol Res. 2003 Aug;48(2):193-8.  

Chemical & Physical Properties

[ Density]:
1.084 g/cm3

[ Boiling Point ]:
377.4ºC at 760 mmHg

[ Molecular Formula ]:
C9H15N3

[ Molecular Weight ]:
165.23500

[ Flash Point ]:
182.1ºC

[ Exact Mass ]:
165.12700

[ PSA ]:
40.71000

[ LogP ]:
1.28060

[ Vapour Pressure ]:
6.75E-06mmHg at 25°C

[ Index of Refraction ]:
1.544

Related Compounds