astin B

Names

[ Name ]:
astin B

Biological Activity

[Description]:

Astin B is a orally active and potent cyclic pentapeptide, that can be isolated from Aster tataricus. Astin B has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family

Signaling Pathways >> Apoptosis >> Apoptosis

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> Apoptosis >> Caspase

Research Areas >> Metabolic Disease

Signaling Pathways >> MAPK/ERK Pathway >> JNK

[Target]

Bcl-2

Bax

Caspase-3

Caspase-9

[In Vitro]

Astin B (0-60 μM, 12-48 h) 抑制 L-02 细胞的增殖[1]。 Astin B (0-60 μM, 24 h) 诱导氧化应激和线粒体功能障碍，调节 Bcl-2/Bax 表达并增加 caspase-3 和 -9 活性[1]。 Astin B (0-60 μM, 24 h) 在 L-02 细胞中诱导自噬以防止细胞凋亡[1]。 Astin B 在肝细胞中引起氧化应激相关炎症，活性氧 (ROS) 水平升高、细胞内谷胱甘肽 (GSH) 含量降低以及 c-Jun 氨基末端激酶 (JNK) 磷酸化增强得到证实[1]。

[In Vivo]

Astin B (10 mg/kg，口服，每天一次，连续 7 天) 诱导小鼠肝损伤[1]。 Animal Model: Male ICR mice (6–8 weeks of age, 10 per group)[1] Dosage: 10 mg/kg Administration: Orally administered, once daily for 7 consecutive days Result: Induced liver injury in mice. Compared to the control group, the serum levels of ALT and AST in mice treated with astin B were elevated about 11.9 and 2.26 times, respectively.

[References]

[1]. Wang L, et al. Astin B, a cyclic pentapeptide from Aster tataricus, induces apoptosis and autophagy in human hepatic L-02 cells. Chem Biol Interact. 2014 Nov 5;223:1-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₃₃Cl₂N₅O₇

[ Molecular Weight ]:
586.46

astin B

Names

Biological Activity

Chemical & Physical Properties

Related Compounds