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UK-1

Names

[ CAS No. ]:
151271-53-3

[ Name ]:
UK-1

[Synonym ]:
[2,4'-Bibenzoxazole]-4-carboxylicacid,2'-(2-hydroxyphenyl)-,methyl ester
2'-(2-hydroxyphenyl)-2,4'-bibenzoxazole-4-carboxylic acid methyl ester
UK 1(cytotoxin)
UK 1

Biological Activity

[Description]:

UK-1 is a cytotoxic metabolite from Streptomyces sp. 517-02 and exerts a wide spectrum of potent anticancer activities[1]. UK-1 also inhibits HCV replication[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Anti-infection >> HCV
Research Areas >> Infection

[References]

[1]. Ueki M, et al. UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties. J Antibiot (Tokyo). 1993 Jul;46(7):1089-94.

[2]. Ward DN, et al. UK-1 and structural analogs are potent inhibitors of hepatitis C virus replication. Bioorg Med Chem Lett. 2014 Jan 15;24(2):609-12.

Chemical & Physical Properties

[ Density]:
1.423g/cm3

[ Boiling Point ]:
558.2ºC at 760 mmHg

[ Molecular Formula ]:
C22H14N2O5

[ Molecular Weight ]:
386.35700

[ Flash Point ]:
291.4ºC

[ Exact Mass ]:
386.09000

[ PSA ]:
98.59000

[ LogP ]:
4.79520

[ Vapour Pressure ]:
1.71E-12mmHg at 25°C

[ Index of Refraction ]:
1.687

Related Compounds