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Myristoyl-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH

Names

[ CAS No. ]:
152246-40-7

[ Name ]:
Myristoyl-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH

[Synonym ]:
n-m-rkrtlrrl
myr-n-rkrtlrrl-oh
n-myr-arg-lys-arg-thr-leu-arg-arg-leu
myristoyl-arg-lys-arg-thr-leu-arg-arg-leu
myr-arg-lys-arg-thr-leu-arg-arg-leu-oh
egf-r fragment 651-658,myristoylated

Biological Activity

[Description]:

N-myristoyl-RKRTLRRL inhibits binding of PKC substrates. N-myristoyl-RKRTLRRL inhibits Ca2+- and phosphatidylserine (PS)-dependent histone phosphorylation with IC50 of 5 μM.? histone phosphorylation with IC50 of 80 μM[1][2].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC
Research Areas >> Cancer
Signaling Pathways >> TGF-beta/Smad >> PKC

[References]

[1]. David K Crockett, et al. Identification of proteins from formalin-fixed paraffin-embedded cells by LC-MS/MS. Lab Invest. 2005 Nov;85(11):1405-15.  

[2]. C A O'Brian, et al. A novel N-myristylated synthetic octapeptide inhibits protein kinase C activity and partially reverses murine fibrosarcoma cell resistance to Adriamycin. Invest New Drugs. 1991 May;9(2):169-79.  

Chemical & Physical Properties

[ Molecular Formula ]:
C60H117N21O11

[ Molecular Weight ]:
1308.71000

[ Exact Mass ]:
1307.92000

[ PSA ]:
563.95000

[ LogP ]:
7.89680

Related Compounds