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Rebamipide mofetil

Names

[ CAS No. ]:
1527495-76-6

[ Name ]:
Rebamipide mofetil

[Synonym ]:
2-(4-Morpholinyl)ethyl N-(4-chlorobenzoyl)-3-(2-hydroxy-4-quinolinyl)-D-alaninate
4-Quinolinepropanoic acid, α-[(4-chlorobenzoyl)amino]-2-hydroxy-, 2-(4-morpholinyl)ethyl ester, (αR)-

Biological Activity

[Description]:

Rebamipide mofetil is an orally active prodrug of Rebamipide (OPC12759). Rebamipide is a mucoprotective agent. Rebamipide induces COX-2 expression, increases PGE2 levels, and enhances gastric mucosal defense in a COX-2-dependent manner[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX

[References]

[1]. Cho, Eui Hwan, et al.Pharmaceutical composition comprising rebamipide precursor for oral administration for preventing or treating immune disease and metabolic disease.WO2017138717A1.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
743.9±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H26ClN3O5

[ Molecular Weight ]:
483.94

[ Flash Point ]:
403.7±32.9 °C

[ Exact Mass ]:
483.156097

[ LogP ]:
3.06

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.630

Related Compounds