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LY 295427

Names

[ CAS No. ]:
152755-31-2

[ Name ]:
LY 295427

[Synonym ]:
[4α,5α]-4-(2-propenyl)cholestan-3α-ol
(3α,4α,5α)-4-(2-propenyl)cholestan-3-ol
(3R,4S,5S,8S,9S,10R,13R,14S,17R)-4-Allyl-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-ol

Biological Activity

[Description]:

LY 295427 is a LDL receptor modulator and a hypocholesterolemic agent. LY 295427 derepresses the transcription of the LDLR (LDL Receptor). LY 295427 can be used for hypercholesterolemia research[1][2][3].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

LY 295427 时间依赖性地增加中国仓鼠卵巢 (CHO) 细胞对 25-OH chol 的摄取[1]。 LY 295427 (2.9 μM) 提高 30% LDL 受体启动子的活性[2]。

[In Vivo]

LY 295427 剂量依赖性地降低胆固醇-椰子油喂养的仓鼠 LDL-R 转录水平，ED50 值为 40 mg/kg/day[3]。

[References]

[1]. Bowling N, et al. LY295427, a novel hypocholesterolemic agent, enhances [3H]25-hydroxycholesterol binding to liver cytosolic proteins. J Lipid Res. 1996 Dec;37(12):2586-98.  

[2]. George Chang, et al. Low density lipoprotein receptor up-regulation. Expert Opinion on Therapeutic Patents. Volume 9, 1999-Issue 5.

[3]. Bensch WR, et al. Effects of LY295427, a low-density lipoprotein (LDL) receptor up-regulator, on LDL receptor gene transcription and cholesterol metabolism in normal and hypercholesterolemic hamsters. J Pharmacol Exp Ther. 1999 Apr;289(1):85-92.  

Chemical & Physical Properties

[ Molecular Formula ]:
C30H52O

[ Molecular Weight ]:
428.73300

[ Exact Mass ]:
428.40200

[ PSA ]:
20.23000

[ LogP ]:
8.27080

Related Compounds