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Nolatrexed dihydrochloride

Names

[ CAS No. ]:
152946-68-4

[ Name ]:
Nolatrexed dihydrochloride

[Synonym ]:
2-Amino-6-methyl-5-(4-pyridinylsulfanyl)-4(1H)-quinazolinone dihydrochloride
Thymitaq
2-Amino-6-methyl-5-(pyridin-4-ylsulfanyl)quinazolin-4(3H)-one dihydrochloride
MFCD00917041
4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio)-, hydrochloride (1:2)
Nolatrexed dihydrochloride
AG 337

Biological Activity

[Description]:

Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase[1]. Nolatrexed dihydrochloride (AG 337) has anti-cancer activity, induces cell cycle arrest in S phase of cancer cells[2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Thymidylate Synthase
Research Areas >> Cancer

[Target]

Ki: 11 nM (Human Thymidylate Synthase)[1]


[References]

[1]. Webber S, et al. AG337, a novel lipophilic thymidylate synthase inhibitor: in vitro and in vivo preclinical studies. Cancer Chemother Pharmacol. 1996;37(6):509-17.

[2]. McGuire JJ, et al. Characterization of the effect of AG337, a novel lipophilic thymidylate synthase inhibitor, on human head and neck and human leukemia cell lines.

Chemical & Physical Properties

[ Boiling Point ]:
493.6ºCat 760 mmHg

[ Melting Point ]:
301-302ºC

[ Molecular Formula ]:
C14H14Cl2N4OS

[ Molecular Weight ]:
357.258

[ Flash Point ]:
252.3ºC

[ Exact Mass ]:
356.026550

[ PSA ]:
109.96000

[ LogP ]:
4.54510

[ Storage condition ]:
Hygroscopic, -20°C Freezer, Under Inert Atmosphere

[ Stability ]:
Hygroscopic

Related Compounds