Clibucaine

Names

[ Name ]:
Clibucaine

[Synonym ]:
Clibucaina
3-Piperidino-buttersaeure-(2,4-dichlor-anilid)
Clibucaine
Clibucaina [INN-Spanish]
3-piperidino-butyric acid-(2,4-dichloro-anilide)
Clibucainum [INN-Latin]

Biological Activity

[Description]:

Clibucaine is a piperidine derivative possessing local anesthetic properties. Clibucaine can be used as a local anesthetic agent[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Dennie Van Den Heuvel, et al. Gastro-retentive oral dosage unit containing a local anaesthetic. Patent, WO2023094100A1.

Chemical & Physical Properties

[ Density]:
1.255g/cm3

[ Boiling Point ]:
466.8ºC at 760mmHg

[ Molecular Formula ]:
C₁₅H₂₀Cl₂N₂O

[ Molecular Weight ]:
315.24

[ Flash Point ]:
236.1ºC

[ Exact Mass ]:
314.09500

[ PSA ]:
35.83000

[ LogP ]:
4.78380

[ Vapour Pressure ]:
6.86E-09mmHg at 25°C

[ Index of Refraction ]:
1.585

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TN3712310

CHEMICAL NAME :: 1-Piperidinepropionanilide, 2',4'-dichloro-beta-methyl-

CAS REGISTRY NUMBER :: 15302-10-0

BEILSTEIN REFERENCE NO. :: 0249881

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C15-H20-Cl2-N2-O

MOLECULAR WEIGHT :: 315.27

WISWESSER LINE NOTATION :: T6NTJ AY1&1VMR BG DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 38,1085,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 38,1085,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 59 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 38,1085,1955

Safety Information

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%