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m-PEG3-0-benzaldehyde

Names

[ CAS No. ]:
153364-63-7

[ Name ]:
m-PEG3-0-benzaldehyde

[Synonym ]:
Benzaldehyde, 4-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-
4-{2-[2-(2-Methoxyethoxy)ethoxy]ethoxy}benzaldehyde
MFCD22683279

Biological Activity

[Description]:

m-PEG3-0-benzaldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
383.8±32.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H20O5

[ Molecular Weight ]:
268.306

[ Flash Point ]:
168.4±25.2 °C

[ Exact Mass ]:
268.131073

[ LogP ]:
0.65

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.510

Related Compounds