S1P Lyase inhibitor 31

A potent, selective and orally bioavailable S1P lyase (S1PL) inhibitor with enzyme IC50 of 44 nM, cell IC50 of 110 nM; displays acceptable selectivity in a panel of 74 receptors and enzymes at 10 uM; induces profound reduction of peripheral T cell numbers after oral dosage and confers pronounced protection in a rat model of multiple sclerosis.

References 1. Harris CM, et al. J Pharmacol Exp Ther. 2016 Oct;359(1):151-8. 2. Weiler S, et al. J Med Chem. 2014 Jun 26;57(12):5074-84. View Related Products by Target Other Targets