carboxyebselen

Names

[ Name ]:
carboxyebselen

[Synonym ]:
4-(3-Oxo-1,2-benzoselenazol-2(3H)-yl)benzoic acid
Carboxyebselen
4-(1,2-benzisoselenazol-3-(2H)-one-2-yl)benzoic acid
Hooc-ebs
Benzoic acid,4-(3-oxo-1,2-benzisoselenazol-2(3H)-yl)
2-(carboxyphenyl)-1,2-benzisoselenazol-3(2H)-one
4-(2,3-dihydro-3-oxo-1,2-benzisoselenazol-2-yl)benzoic acid

Biological Activity

[Description]:

Carboxyebselen (HOOC-Ebs) is a potent and selective inhibitor of endothelial nitric oxide synthase (eNOS)[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

[In Vivo]

Carboxyebselen (HOOC-Ebs), a derivative of Ebselen (Ebs) inhibits NOS present in enzymatic preparations from bovine endothelium, porcine cerebella, and murine spleen, however, it is both more potent and more selective for the constitutive endothelial NOS than Ebs. Unlike Ebs, HOOC-Ebs (0.1-30 microM) causes a concentration-dependent endothelium-independent relaxations of rings of rabbit aorta[1].

[References]

[1]. Hatchett RJ, et al. Carboxyebselen a potent and selective inhibitor of endothelial nitric oxide synthase. J Physiol Pharmacol. 1994;45(1):55-67.

Chemical & Physical Properties

[ Boiling Point ]:
531.5ºC at 760mmHg

[ Molecular Formula ]:
C₁₄H₉NO₃Se

[ Molecular Weight ]:
318.18600

[ Flash Point ]:
275.3ºC

[ Exact Mass ]:
318.97500

[ PSA ]:
59.30000

[ LogP ]:
1.74590

[ Vapour Pressure ]:
3.96E-12mmHg at 25°C

carboxyebselen

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Related Compounds