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PF-470

Names

[ CAS No. ]:
1539296-45-1

[ Name ]:
PF-470

[Synonym ]:
1-Methyl-3-(4-methyl-3-pyridinyl)-6-(2-pyridinylmethoxy)-1H-pyrazolo[3,4-b]pyrazine
PF-06297470
MFCD28100803
1H-Pyrazolo[3,4-b]pyrazine, 1-methyl-3-(4-methyl-3-pyridinyl)-6-(2-pyridinylmethoxy)-

Biological Activity

[Description]:

A highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator with Ki of 0.9 nM, IC50 of 2.5 nM; demonstrates robust efficacy in MPTP-rendered Parkinsonian nonhuman primate model of l-DOPA-induced dyskinesia (PD-LID), but with delayed-type immune-mediated type IV hypersensitivity.

[References]

References 1. Zhang L, et al. J Med Chem. 2014 Feb 13;57(3):861-77. View Related Products by Target mGluR

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
526.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H16N6O

[ Molecular Weight ]:
332.359

[ Flash Point ]:
272.4±28.7 °C

[ Exact Mass ]:
332.138550

[ LogP ]:
1.13

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.699

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
NONH for all modes of transport

Related Compounds