DL-5-Fluorotryptophan

Names

[ CAS No. ]:
154-08-5

[ Name ]:
DL-5-Fluorotryptophan

[Synonym ]:
2-amino-3-(5-fluoro-1H-indol-3-yl)propanoic acid
5-Fluoro-DL-tryptophan
H-5-FLUORO-DL-TRP-OH
5-Fluoro D,L-tryptophan
5-fluoro-DL-Trp
5-Fluoro-D,L-tryptophan
DL-5-FLUOROTRYPTOPHAN
MFCD00005649
EINECS 205-822-5
5-Fluorotryptophan
5-Fluoro-DL-tryptophane
Tryptophan, 5-fluoro-

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
450.7±45.0 °C at 760 mmHg

[ Melting Point ]:
265 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₁H₁₁FN₂O₂

[ Molecular Weight ]:
222.216

[ Flash Point ]:
226.4±28.7 °C

[ Exact Mass ]:
222.080460

[ PSA ]:
79.11000

[ LogP ]:
1.17

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.673

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YN6825000

CHEMICAL NAME :: Tryptophan, 5-fluoro-, DL-

CAS REGISTRY NUMBER :: 154-08-5

BEILSTEIN REFERENCE NO. :: 0022753

LAST UPDATED :: 199803

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H11-F-N2-O2

MOLECULAR WEIGHT :: 222.24

WISWESSER LINE NOTATION :: T56 BMJ D1YZVQ GF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 776 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 15,2134,1966

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/38

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
YN6825000

[ HS Code ]:
2933990090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin.

J. Med. Chem. 49(15) , 4616-22, (2006)

Tryptophans at positions 4 and 7 of compstatin, a peptide complement inhibitor, are crucial for its interaction with C3. However, the nature of their involvement has not been studied to date. Here we ...

Ionization potentials of fluoroindoles and the origin of nonexponential tryptophan fluorescence decay in proteins.

J. Am. Chem. Soc. 127(11) , 4104-13, (2005)

This work reports an explanation for the unusual monoexponential fluorescence decay of 5-fluorotryptophan (5FTrp) in single-Trp mutant proteins [Broos, J.; Maddalena, F.; Hesp, B. H. J. Am. Chem. Soc....

In vivo synthesized proteins with monoexponential fluorescence decay kinetics.

J. Am. Chem. Soc. 126(1) , 22-3, (2004)

Tryptophan, when in a protein, typically shows multiexponential fluorescence decay kinetics. Complex kinetics prevents a straightforward interpretation of time-resolved fluorescence protein data, part...