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Prunetrin

Names

[ CAS No. ]:
154-36-9

[ Name ]:
Prunetrin

[Synonym ]:
3-(4-β-D-glucopyranosyloxy-phenyl)-5-hydroxy-7-methoxy-chromen-4-one
5-Hydroxy-7-methoxy-3-[4-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-phenyl]-chromen-4-one
prunetin-4'-O-β-D glucopyranoside
prunetrin
Prunetin 4'-O-β-D-glucopyranoside
prunetin 4'-O-[β-D-glucopyranoside]
4',5-dihydroxy-7-methoxyisoflavone-4'-O-β-D-glucopyranoside

Biological Activity

[Description]:

Prunetin (Trifoside), an O-methylated isoflavone found in Prunus yedoensis, possesses anti-inflammatory activities[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vitro]

Prunetin inhibits LPS-induced nitric oxide and prostaglandin E2 production through the suppression of iNOS and COX-2 at the transcriptional level[1]. Prunetin inhibits lipopolysaccharide-induced inflammatory cytokine production and MUC5AC expression by inactivating the TLR4/MyD88 pathway in human nasal epithelial cells[2].

[References]

[1]. Yang G, et al. Anti-inflammatory effect of prunetin via the suppression of NF-κB pathway. Food Chem Toxicol. 2013;58:124-132.

[2]. Hu H, et al. Prunetin inhibits lipopolysaccharide-induced inflammatory cytokine production and MUC5AC expression by inactivating the TLR4/MyD88 pathway in human nasal epithelial cells. Biomed Pharmacother. 2018;106:1469-1477.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H22O10

[ Molecular Weight ]:
446.40400

[ Exact Mass ]:
446.12100

[ PSA ]:
159.05000

[ LogP ]:
0.35290

Related Compounds