<Suppliers Price>

Biotin-sar-oh

Names

[ CAS No. ]:
154024-76-7

[ Name ]:
Biotin-sar-oh

[Synonym ]:
MFCD11113162
N-Methyl-N-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}glycine
Glycine, N-[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]-N-methyl-
(+)-Biotin-sarcosine
[{5-[(3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}(methyl)amino]acetic acid

Biological Activity

[Description]:

Biotin-sar-oh is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Density]:
1.3±0.0 g/cm3

[ Boiling Point ]:
646.1±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H21N3O4S

[ Molecular Weight ]:
315.388

[ Flash Point ]:
344.5±0.0 °C

[ Exact Mass ]:
315.125275

[ LogP ]:
0.32

[ Vapour Pressure ]:
0.0±0.0 mmHg at 25°C

[ Index of Refraction ]:
1.549

Related Compounds