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Sibenadet hydrochloride

Names

[ CAS No. ]:
154189-24-9

[ Name ]:
Sibenadet hydrochloride

[Synonym ]:
Sibenadet HCl
Sibenadet hydrochloride
Viozan

Biological Activity

[Description]:

Sibenadet hydrochloride (AR-C68397AA) is a dual D2 dopamine receptor, beta2-adrenoceptor agonist with bronchodilator activity. Investigation in animal models of key chronic obstructive pulmonary disease (COPD) symptoms has demonstrated that Sibenadet hydrochloride effectively inhibits sensory nerve activity, thereby reducing reflex cough, mucus production and tachypnoea.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

[References]

[1]. Ind PW, Laitinen L, Laursen L, et al. Early clinical investigation of Viozan (sibenadet HCl), a novel D2 dopamine receptor, beta2-adrenoceptor agonist for the treatment of chronic obstructive pulmonary disease symptoms. Respir Med. 2003;97 Suppl A:S9-S21.

Chemical & Physical Properties

[ Boiling Point ]:
717ºC at 760mmHg

[ Molecular Formula ]:
C22H29ClN2O5S2

[ Molecular Weight ]:
501.05900

[ Flash Point ]:
387.4ºC

[ Exact Mass ]:
500.12100

[ PSA ]:
145.11000

[ LogP ]:
4.76520

[ Vapour Pressure ]:
3.06E-21mmHg at 25°C

Related Compounds