Cosalane

Names

[ CAS No. ]:
154212-56-3

[ Name ]:
Cosalane

[Synonym ]:
TETRANOR-PGFM
tetranor-PGFM Lipid Maps MS Standard
TETRANOR PROSTAGLANDIN F METABOLITE

Biological Activity

[Description]:

Cosalane (NSC 658586) is a potent inhibitor of HIV replication. Cosalane has an intrinsic ability to block human and murine CCR7 function in vitro in response to both of its natural ligands, CCL19 and CCL21, with the IC50 of 0.207/2.66 μM in human for CCL19/CCL21 and 0.193/1.98 μM in murine, respectively[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CCR
Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection
Signaling Pathways >> Immunology/Inflammation >> CCR

[Target]

Human CCR7

Murine CCR7


[References]

[1]. Kenneth A Fowler, et al. The Ex Vivo Treatment of Donor T Cells with Cosalane, an HIV Therapeutic and Small-Molecule Antagonist of CC-Chemokine Receptor 7, Separates Acute Graft-versus-Host Disease from Graft-versus-Leukemia Responses in Murine Hematopoietic Stem Cell Transplantation Models. Biol Blood Marrow Transplant. 2019 Jun;25(6):1062-1074.  

[2]. Emily A Hull-Ryde, et al. Identification of Cosalane as an Inhibitor of Human and Murine CC-Chemokine Receptor 7 Signaling via a High-Throughput Screen. SLAS Discov. 2018 Dec;23(10):1083-1091.  

Chemical & Physical Properties

[ Density]:
1.191g/cm3

[ Boiling Point ]:
797.4ºC at 760mmHg

[ Molecular Formula ]:
C45H60Cl2O6

[ Molecular Weight ]:
767.86000

[ Flash Point ]:
436.1ºC

[ Exact Mass ]:
766.37700

[ PSA ]:
115.06000

[ LogP ]:
12.75040

[ Vapour Pressure ]:
7.99E-27mmHg at 25°C

Synthetic Route

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