Pomalidomide-6-OH

Names

[ Name ]:
Pomalidomide-6-OH

[Synonym ]:
4-Amino-2-(2,6-dioxo-3-piperidinyl)-6-hydroxy-1H-isoindole-1,3(2H)-dione
1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-6-hydroxy-

Biological Activity

[Description]:

Pomalidomide-6-OH is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-OH can be connected to the ligand for protein by a linker to form PROTAC[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

Cereblon

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Andrew J. Phillips, et al. Bromodomain targeting degronimers for target protein degradation. WO2017197056A1.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
674.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₁N₃O₅

[ Molecular Weight ]:
289.24

[ Flash Point ]:
361.8±31.5 °C

[ Exact Mass ]:
289.069885

[ LogP ]:
-1.34

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.725

[ Storage condition ]:
2-8°C

Pomalidomide-6-OH

Names

Biological Activity

Chemical & Physical Properties

Related Compounds