Pomalidomide-6-O-CH3

Names

[ Name ]:
Pomalidomide-6-O-CH3

Biological Activity

[Description]:

Pomalidomide-6-O-CH3 is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-O-CH3 can be connected to the ligand for protein by a linker to form PROTAC[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

Cereblon

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Andrew J. Phillips, et al. Bromodomain targeting degronimers for target protein degradation. WO2017197056A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₃N₃O₅

[ Molecular Weight ]:
303.27

[ Storage condition ]:
2-8°C

Pomalidomide-6-O-CH3

Names

Biological Activity

Chemical & Physical Properties

Related Compounds