Chlortoluron

Names

[ Name ]:
Chlortoluron

[Synonym ]:
Chlorotoluron
Methanol, 1-[(3-chloro-4-methylphenyl)imino]-1-(dimethylamino)-, (E)-
Urea, N'-(3-chloro-4-methylphenyl)-N,N-dimethyl-
N’-(3-chloro-4-methylphenyl)-N,N-dimethylurea
3-(3-Chloro-4-methylphenyl)-1,1-dimethylurea
MFCD00018275
Chlortoluron
3-(3-chloro-p-tolyl)-1,1-dimethylurea
EINECS 239-592-2
3-(3-Chloro-4-methyl)-1,1-dimethylurea
N'-(3-Chloro-4-methylphenyl)-N,N-dimethylcarbamimidic acid

Biological Activity

[Description]:

Chlorotoluron (Chlortoluron) is a substituted phenylurea herbicide, is widely used for selective weed control in cereals crops and is an environmental pollutant[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Z Mehmood, et al. Metabolism of the Herbicide Chlortoluron by Human Cytochrome P450 3A4. Chemosphere. 1995 Dec;31(11-12):4515-29.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
345.9±52.0 °C at 760 mmHg

[ Melting Point ]:
147-148ºC

[ Molecular Formula ]:
C₁₀H₁₃ClN₂O

[ Molecular Weight ]:
212.676

[ Flash Point ]:
163.0±30.7 °C

[ Exact Mass ]:
212.071640

[ PSA ]:
32.34000

[ LogP ]:
2.62

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.541

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YS7230000

CHEMICAL NAME :: Urea, 3-(3-chloro-p-tolyl)-1,1-dimethyl-

CAS REGISTRY NUMBER :: 15545-48-9

BEILSTEIN REFERENCE NO. :: 2647688

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C10-H13-Cl-N2-O

MOLECULAR WEIGHT :: 212.70

WISWESSER LINE NOTATION :: GR B1 EMVN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1300 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 21 gm/kg/90D-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2 gm/kg

SEX/DURATION :: female 4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 10 mg/kg

SEX/DURATION :: male 50 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,353,1978

Safety Information

[ Symbol ]:

GHS08, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H351-H361d-H410

[ Precautionary Statements ]:
P273-P281-P501

[ Hazard Codes ]:
Xn:Harmful;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R40;R50/53;R63

[ Safety Phrases ]:
S26-S36/37-S46-S60-S61-S16

[ RIDADR ]:
UN 3077

[ RTECS ]:
YS7230000

[ HS Code ]:
2924299035

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299035

[ Summary ]:
2924299035 2-chlorobenzaldehyde。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

Articles

Assessing the potential for algae and macrophytes to degrade crop protection products in aquatic ecosystems.

Environ. Toxicol. Chem. 30(3) , 622-31, (2011)

Rates of pesticide degradation in aquatic ecosystems often differ between those observed within laboratory studies and field trials. Under field conditions, a number of additional processes may well h...

Polymer monolith microextraction using poly(butyl methacrylate-co-1,6-hexanediol ethoxylate diacrylate) monolithic sorbent for determination of phenylurea herbicides in water samples.

Talanta 147 , 199-206, (2015)

In this study, recently developed 1,6-hexanediol ethoxylate diacrylate (HEDA)-based polymeric monoliths were utilized as sorbents for efficient extraction of phenylurea herbicides (PUHs) from water sa...

Analysis of trace levels of pesticides in rainwater by SPME and GC-tandem mass spectrometry after derivatisation with PFBBr.

Anal. Bioanal. Chem 387(1) , 359-68, (2007)

Solid-phase microextraction (SPME) was used for the analysis of some pesticides (bromoxynil, chlorotoluron, diuron, isoproturon, 2,4-MCPA, MCPP and 2,4-D) in rainwater after derivatisation with PFBBr ...