Pizotifen
Names
[ CAS No. ]:
15574-96-6
[ Name ]:
Pizotifen
[Synonym ]:
4-(1-Methyl-4-piperidylidene)-9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophene
4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-1-methylpiperidine
UNII:0BY8440V3N
Piperidine, 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methyl-
Pizotyline
EINECS 239-632-9
Piperidine, 4-(9,10-dihydro-4H-benzo(4,5)cyclohepta(1,2-b)thien-4-ylidene)-1-methyl-
Pizotifen
Sandomigran
4-(4,5-dihydrobenzo[1,2]cyclohepta[3,4-b]thiophen-10-ylidene)-1-methylpiperidine
4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine
MFCD00864192
Biological Activity
[Description]:
[Related Catalog]:
[Target]
5-HT2A Receptor
5-HT1C Receptor
[In Vitro]
[In Vivo]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
436.7±45.0 °C at 760 mmHg
[ Melting Point ]:
140-142°C
[ Molecular Formula ]:
C19H21NS
[ Molecular Weight ]:
295.442
[ Flash Point ]:
217.9±28.7 °C
[ Exact Mass ]:
295.139465
[ PSA ]:
31.48000
[ LogP ]:
6.13
[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C
[ Index of Refraction ]:
1.631
[ Storage condition ]:
Refrigerator
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TM7165000
- CHEMICAL NAME :
- Piperidine, 4-(9,10-dihydro-4H-benzo(4,5)cyclohepta(1,2-b)thien-4 -ylidene)-1-methyl-
- CAS REGISTRY NUMBER :
- 15574-96-6
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C19-H21-N-S
- MOLECULAR WEIGHT :
- 295.47
- WISWESSER LINE NOTATION :
- T C576 BY FS&T&J BU- DT6N DYTJ A1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 12857 ug/kg/12D-I
- TOXIC EFFECTS :
- Liver - jaundice, other or unclassified
- REFERENCE :
- AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 144,815,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 410 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 12,297,1970
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H361
[ Precautionary Statements ]:
P281
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
36/37/38
[ Safety Phrases ]:
26-37/39
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
TM7165000
Articles
J. Pharm. Biomed. Anal. 111 , 333-43, (2015)
Supercritical fluid chromatography (SFC) is drawing considerable interest as separation technique in the pharmaceutical industry. The technique is already well established in chiral separations both a...
Efficacy of amitriptyline, pizotifen and propranolol in the prevention of migraine.Mymensingh Med. J. 22(1) , 93-100, (2013)
This intervention study conducted in the Neurology outpatient Department of Mymensingh Medical College Hospital (MMCH) from January 2006 to December 2007 to compare efficacy of amitriptyline, pizotife...
Potential vascular alpha1-adrenoceptor blocking properties of an array of 5-HT receptor ligands in the rat.Eur. J. Pharmacol. 535(1-3) , 234-42, (2006)
This study set out to analyse the potential ability of some 5-hydroxytryptamine (5-HT) receptor ligands widely used in cardiovascular experimental models to interact with vascular alpha1-adrenoceptors...