BW 373U86

Names

[ CAS No. ]:
155836-50-3

[ Name ]:
BW 373U86

[Synonym ]:
SNC 86
(+)-4-[α(R)-α-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-hydroxyphenyl)methyl]-N,N-diethylbenzamide
(+)-BW373U86
SNC86
4-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N,N-diethylbenzamide
BW373486

Biological Activity

[Description]:

BW373U86 (SNC86) is a δ-opioid receptor agonist with an IC50 of 1.49 nM. BW373U86 shows antidepressant-like effects[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor
Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
Research Areas >> Neurological Disease

[Target]

IC50: 1.49 nM (δ-opioid receptor)[1]


[References]

[1]. Jutkiewicz EM, et al. Delta-opioid agonists: differential efficacy and potency of SNC80, its 3-OH (SNC86) and 3-desoxy (SNC162) derivatives in Sprague-Dawley rats. J Pharmacol Exp Ther. 2004 Apr;309(1):173-81.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H37N3O2

[ Molecular Weight ]:
435.60

[ Exact Mass ]:
435.28900

[ PSA ]:
47.02000

[ LogP ]:
4.42000

Related Compounds