Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat) trifluoroacetate salt

Names

[ Name ]:
Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat) trifluoroacetate salt

[Synonym ]:
L-Threonyl-L-arginyl-L-seryl-L-alanyl-L-tryptophanamide
Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat)

Biological Activity

[Description]:

Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat) (Human PTHrP (107-111) amide) is a C-terminal parathyroid hormone-related protein fragment that can inhibit bone resorption[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Murrills RJ, et al. Lack of significant effect of carboxyl-terminal parathyroid hormone-related peptide fragments on isolated rat and chick osteoclasts. Calcif Tissue Int. 1995 Jul;57(1):47-51.

[2]. Whitfield JF, et al. C-terminal fragments of parathyroid hormone-related protein, PTHrP-(107-111) and (107-139), and the N-terminal PTHrP-(1-40) fragment stimulate membrane-associated protein kinase C activity in rat spleen lymphocytes. J Cell Physiol. 1994 Mar;158(3):518-22.

Chemical & Physical Properties

[ Density]:
1.53±0.1 g/cm3

[ Molecular Formula ]:
C₂₇H₄₂N₁₀O₇

[ Molecular Weight ]:
618.69

[ Exact Mass ]:
618.32400

[ PSA ]:
303.66000

[ LogP ]:
0.27360

[ Water Solubility ]:
Very slightly soluble (0.87 g/L) (25 ºC)