Thymine-d4-1

Names

[ Name ]:
Thymine-d4-1

[Synonym ]:
Thymine-methyl-d3-6-d
MFCD01075460

Biological Activity

[Description]:

Thymine-d4-1 is the deuterium labeled Thymine[1]. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM[2].

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Tuchman M, et al. Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase. Cancer Res. 1985 Nov;45(11 Pt 1):5553-6.

Chemical & Physical Properties

[ Density]:
1.266g/cm3

[ Melting Point ]:
325-327ºC(lit.)

[ Molecular Formula ]:
C₅H₂D₄N₂O₂

[ Molecular Weight ]:
130.13800

[ Exact Mass ]:
130.06800

[ PSA ]:
58.53000

[ Index of Refraction ]:
1.489

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3