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MART-1 (26-35) (human) trifluoroacetate salt

Names

[ CAS No. ]:
156251-01-3

[ Name ]:
MART-1 (26-35) (human) trifluoroacetate salt

[Synonym ]:
Melan-A,MART 1 (26-35)
ANTIGEN SK29-AA (26-35) (HUMAN)
L-α-Glutamyl-L-alanyl-L-alanylglycyl-L-isoleucylglycyl-L-isoleucyl-L-leucyl-L-threonyl-L-valine
MART-1 (26-35) (HUMAN)
GLU-ALA-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL
ANTIGEN LB39-AA (26-35) (HUMAN)
MELAN-A PROTEIN (26-35) (HUMAN)
EAAGIGILTV
L-Valine, L-α-glutamyl-L-alanyl-L-alanylglycyl-L-isoleucylglycyl-L-isoleucyl-L-leucyl-L-threonyl-
MART-1 (26-35),human (3)
MELAN-A
MART 1 (26-35)

Biological Activity

[Description]:

MART-1 (26-35) is amino acid residue 26 to 35 of MART-1 protein.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Peptides
Research Areas >> Inflammation/Immunology

[In Vitro]

MART-1 (Melan-A) gene is 18 kb long and comprises five exons. It is expressed in most melanoma tumor samples, and among normal cells, only in melanocytes[1]. In cancer immunotherapy, epitopes and variants derived from the MART-1/Melan-A protein are widely used as clinical vaccines. The epitopes spanning amino acid residues 26–35 and 27–35 from the MART-1/Melan-A protein, highly expressed in melanoma cells, provide a prime example of T cell recognition of multiple peptides and the use of peptide variants designed to elicit altered immunological responses[2].

[References]

[1]. Coulie PG, et al. A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J Exp Med. 1994 Jul 1;180(1):35-42.

[2]. Borbulevych OY, et al. Structures of MART-126/27-35 Peptide/HLA-A2 complexes reveal a remarkable disconnect between antigen structural homology and T cell recognition. J Mol Biol. 2007 Oct 5;372(5):1123-36.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
1358.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C42H74N10O14

[ Molecular Weight ]:
943.096

[ Flash Point ]:
775.3±34.3 °C

[ Exact Mass ]:
942.538574

[ PSA ]:
382.75000

[ LogP ]:
1.19

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.527

Related Compounds